Americans are living longer and are more active than ever. Medications are playing an important role for better health, especially for older adults that are more likely living with one or more chronic illnesses. Most patients 65 and older have at least one chronic health condition and are taking multiple medications. Advances in medicine have led to earlier diagnosis and improved treatment of chronic conditions. However, medication use and adherence in older adults are also more likely to be associated with increased safety concerns. Recognizing the benefits of medicine, while minimizing and managing the risks is important to chronic care management.